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ivermectin 3mg for humans Pharmacologic treatment options include the following Antihistamines primarily those that block H receptors such as diphenhydramine hydroxyzine fexofenadine loratadine desloratadine cetirizine and levocetirizine firstline therapy H antihistamines such as cimetidine famotidine and ranitidine have a role when used in combination with H antihistamines Doxepin Glucocorticoids Epinephrine controversial in acute urticaria Methotrexate colchicine dapsone indomethacin and hydroxychloroquine for vasculitic urticaria Patients with chronic or recurrent urticaria should be referred to a dermatologist for further evaluation and management.